Garcinia mangostana, commonly known as mangosteen, is a tropical fruit that’s long been popular in its native Southeast Asia. In recent years, as rumors about it’s health-promoting properties began to spread, the world at large became more familiar with this exotic fruit. Despite the name, mangosteen is not related to the mango, although it’s a delightful—albeit delicately flavored—food when ripe. Outside of Asia, the public has arguably been more interested in the inedible outer hull, which protects the tender ripening fruit. It is this tough, purple outer layer—technically called the pericarp—that has long been used as a medicinal plant throughout Southeast Asia.

Numerous Promising Activities

Reputed to possess potent anti-inflammatory properties, it’s most commonly used in traditional folk medicine as a treatment for wounds and skin infections. It’s also used to combat diarrhea and other intestinal complaints. Now, emerging evidence suggests mangosteen may possess numerous other potentially beneficial properties. For example, Chinese researchers reported in 2011 that a class of chemicals from mangosteen—the xanthones—may act as potent natural cancer fighters. “Multiple lines of evidence from numerous…studies have confirmed that xanthones inhibit proliferation of a wide range of human tumor cell types by modulating various targets and signaling transduction pathways,” the researchers wrote.

Although controlled clinical trials on human subjects are lacking, scientific interest in mangosteen is increasing. Mangosteen juice is a popular nutritional supplement around the world, primarily touted for its unique antioxidants. Research suggests that mangosteen xanthones are responsible for many of mangosteen’s reported health benefits. Xanthones are extracted from the inedible, protective husk that surrounds the delicate fruit, as well as from the whole fruit, heartwood, and leaves of Garcinia mangostana.

At last count, at least 80 different xanthones had been identified in mangosteen pericarp. These newly identified compounds represent a potential goldmine for scientists seeking new ways to prevent and/or treat diseases, such as cancer. “Xanthones…from mangosteen…are known to possess a wide spectrum of pharmacologic properties, including antioxidant, anti- tumor, anti-allergic, anti-inflammatory, anti-bacterial, anti-fungal, and anti-viral activities,” wrote Chinese researchers, in Current Molecular Medicine.

Potential Support for Healthy Cell Function

Investigations are preliminary, and the United States Food and Drug Administration has not approved mangosteen products for the treatment of any illness, but emerging research is promising. One study, for example, found evidence that xanthones from mangosteen pericarp are capable of exerting effects consistent with breast cancer prevention. Investigators at Ohio State University have shown in recent years that some mangosteen xanthones exhibit antioxidant activity, while others apparently act like aromatase inhibitors, a class of drugs used to prevent the growth of hormone-positive breast cancer cells.

Some experiments on rodent models of human colon cancer have suggested that mangosteen xanthones may prevent the development of colon cancer. Evidence suggests that mangosteen xanthones may prevent cancer through a variety of mechanisms, including anti-proliferation by modifying cancerous cell cycles, suppression of invasion and metastasis, induction of programmed cellular suicide (apoptosis), and inactivation of carcinogens, among other effects.

Skeptics are quick to note that anti-cancer activity by mangosteen has not yet been proven in human subjects. But that didn’t temper the apparent enthusiasm of Malaysian scientists, who commented recently on their laboratory investigations with rodent models of human colon cancer. “The xanthones extract, when fed to nude mice, caused significant growth inhibition of the…colorectal carcinoma cells…Our data suggest new mechanisms of action of α-mangostin and the G. mangostana xanthones, and suggest the xanthones extract of as a potential anti-colon cancer candidate.”

Weight Loss Potential?

Alone, Garcinia mangostana shows promise in a variety of health fields.  But when combined with another Ayurvedic botanical its potential starts to shine.  Clinical research conducted on a proprietary blend of Garcina mangosta and Sphaeranthus indicus called Meratrim®.  Published clinical trials show fantastic weight loss and slimming results. Participants in one study published in the journal of Obesity, followed a 2,000 calorie per day diet, and walked 30 minutes a day, five days per week.  Those who were actively taking Meratrim® lost 7.2″ over 8 weeks, vs. the placebo group who lost only 3.6″.  But how about weight loss? Individuals taking Meratrim® (while dieting and exercising)  lost 11.5 lbs over 8 weeks vs. only 3.3 lbs for those taking placebo.  While more research is needed, it’s clear that for those wanting more from their diet and exercise program should look at adding Meratrim® to their regimen.

Finding the Best Meratrim® Supplement

While Meratrim® is available from a variety of sources, SLIMit® with Meratrim® seems to be the best on the market.  This is because it provides a full clinical 800 mg dose of 100% pure Meratrim® with powerful botanicals, antioxidants and minerals to supercharge your body’s natural fat burning metabolism.  Unlike other products it contains no caffeine (or other stimulants) that can cause un-wanted jitteriness (or even worse health problems).  It’s currently available online, or nationwide through your local health food store.

References

Stern JSPeerson JMishra ATSadasiva Rao MVRajeswari KP. Efficacy and tolerability of an herbal formulation for weight management. Obesity (Silver Spring). 2013 May;21(5):921-7. doi: 10.1002/oby.20211.

Stern JSPeerson JMishra ATMathukumalli VSKonda PR. Efficacy and tolerability of an herbal formulation for weight management.

Aisha AF, Abu-Salah KM, Ismail Z, Majid AM. In vitro and in vivo anti-colon cancer effects of Garcinia mangostana xanthones extract. BMC Complement Altern Med. 2012 Jul 20;12:104.

Balunas MJ, Su B, Brueggemeier RW, Kinghorn AD. Xanthones from the botanical dietary supplement mangosteen (Garcinia mangostana) with aromatase inhibitory activity. J Nat Prod. 2008 Jul;71(7):1161-6. doi: 10.1021/np8000255. Epub 2008 Jun 18.

Cui J, Hu W, Cai Z, Liu Y, Li S, Tao W, Xiang H. New medicinal properties of mangostins: analgesic activity and pharmacological characterization of active ingredients from the fruit hull of Garcinia mangostana L. Pharmacol Biochem Behav. 2010 Apr;95(2):166-72. doi: 10.1016/j.pbb.2009.12.021. Epub 2010 Jan 11.

Han AR, Kim JA, Lantvit DD, Kardono LB, Riswan S, Chai H, et al. Cytotoxic xanthone constituents of the stem bark of Garcinia mangostana (mangosteen). J Nat Prod. 2009 Nov;72(11):2028-31. doi: 10.1021/np900517h.

Jung HA, Su BN, Keller WJ, Mehta RG, Kinghorn AD. Antioxidant xanthones from the pericarp of Garcinia mangostana (Mangosteen). J Agric Food Chem. 2006 Mar 22;54(6):2077-82.

Obolskiy D, Pischel I, Siriwatanametanon N, Heinrich M. Garcinia mangostana L.: a phytochemical and pharmacological review. Phytother Res. 2009 Aug;23(8):1047-65. doi: 10.1002/ptr.2730.

Shan T, Ma Q, Guo K, Liu J, Li W, Wang F, Wu E. Xanthones from mangosteen extracts as natural chemopreventive agents: potential anticancer drugs. Curr Mol Med. 2011 Nov;11(8):666-77.

Suksamrarn S, Komutiban O, Ratananukul P, Chimnoi N, Lartpornmatulee N, Suksamrarn A. Cytotoxic prenylated xanthones from the young fruit of Garcinia mangostana. Chem Pharm Bull (Tokyo). 2006 Mar;54(3):301-5.

Watanapokasin R, Jarinthanan F, Jerusalmi A, Suksamrarn S, Nakamura Y, Sukseree S,  et al. Potential of xanthones from tropical fruit mangosteen as anti-cancer agents: caspase-dependent apoptosis induction in vitro and in mice. Appl Biochem Biotechnol. 2010 Oct;162(4):1080-94. doi: 10.1007/s12010-009-8903-6. Epub 2010 Jan 26.

Insulin is arguably one of the most important hormones in the body. You can’t live without it. Until the early 20th century, people whose body’s could not make it—that is, people with diabetes—essentially faced a death sentence. But in the 1920s scientists finally discovered how to extract and purify insulin from the pancreases of animals.

The first large-scale test of the newly discovered substance led to what has to have been one of the most dramatic moments in the annals of medicine: An entire ward full of comatose, dying children was miraculously revived within moments of receiving injections of the stuff. Their families had been holding vigil, helplessly waiting for the unfortunate children to die. Instead, they rejoiced as their children awoke. That early experiment paved the way for the mass production of purified, injectable insulin, and ensured that parents would never again have to watch their children slip into diabetic comas and die.

What Is Insulin?

Produced by specialized cells deep within the pancreas, insulin is a peptide hormone that is released in response to rising blood sugar levels. That rise in blood sugar—glucose—occurs after a meal has been consumed and digested. Carbohydrates from the diet are broken down into their most basic components: glucose molecules.

Cells lining the intestines sense the presence of certain nutrients, such as amino acids, fats, or carbohydrates, and release the “gut hormone” glucagon-like peptide-1 (GLP-1). GLP-1 circulates throughout the bloodstream, and reaches the pancreas, where it stimulates the release of insulin from the beta cells, which produce insulin. Interestingly, the release of insulin is cyclical, rising and falling every few minutes while it’s being released. This natural ebb and flow is believed to render insulin more effective for a number of reasons, and scientists are now working to recreate this rhythm when designing artificial insulin pumps.

In the bloodstream, insulin acts to shepherd glucose molecules into the body’s cells, where glucose is “burned” for energy. Glucose is an important source of energy, but it’s also important to clear glucose from the circulation promptly. Too much glucose circulating in the bloodstream can be harmful. In fact, one of the defining characteristics of people with type 2 diabetes is high blood sugar (hyperglycemia). Diabetic patients with a history of poorly controlled blood sugar can suffer nerve damage and other side effects. They are also at increased risk of developing cardiovascular disease.

Of course, throughout the day healthy people’s blood sugar levels rise and fall. Levels rise following meals, and eventually fall as insulin is released and cells take up glucose. But among people with type 2 diabetes, levels may remain high, because cells have become “insulin resistant.” Insulin resistance is a condition in which cells no longer respond as they once did to the presence of insulin.

Type 2 diabetes

There are two major types of diabetes: type 1 and type 2. Type 1 is less common. Once known as juvenile diabetes, it is an autoimmune condition, in which the body’s immune system misidentifies the beta cells of the pancreas as foreign and destroys them. Like the children in the anecdote at the beginning of this article, type 1 patients are fully dependent on pharmaceutical insulin for survival.

Type 2 diabetes is far more common. It is considered a lifestyle disease, because it’s linked to obesity, inactivity and poor diet. Evidence suggests it may be prevented or reversed through dietary and lifestyle changes (e.g. avoidance of sugary soft drinks, engaging in regular exercise, eating a Mediterranean diet, etc.) if it has not progressed too far. Eventually, type 2 diabetics may become dependent on synthetic insulin.

Unlike type 1, type 2 diabetes never happens overnight. A condition called “prediabetes” usually precedes the development of full-blown type 2 diabetes. As insulin resistance increases, the body responds by producing and releasing ever-increasing amounts of insulin. This is the body’s attempt to compensate for growing insulin insensitivity. Eventually, the beta cells of the pancreas “burn out,” leaving a patient incapable of producing any insulin. At this point a patient becomes dependent on regular injections of synthetic insulin to survive.

References

Bollyky J, Sanda S, Greenbaum CJ. Type 1 diabetes mellitus: primary, secondary, and tertiary prevention. Mt Sinai J Med. 2008 Aug;75(4):385-97. doi: 10.1002/msj.20054.

Edelman SV. Type II diabetes mellitus. Adv Intern Med. 1998;43:449-500.

Khavandi K, Amer H, Ibrahim B, Brownrigg J. Strategies for preventing type 2 diabetes: an update for clinicians. Ther Adv Chronic Dis. 2013 Sep;4(5):242-61. doi: 10.1177/2040622313494986.

Kojima H, Fujimiya M, Terashima T, Kimura H, Chan L. Extrapancreatic proinsulin/insulin-expressing cells in diabetes mellitus: is history repeating itself? Endocr J. 2006 Dec;53(6):715-22. Epub 2006 Sep 7.

Koopman RJ, Swofford SJ, Beard MN, Meadows SE. Obesity and metabolic disease. Prim Care. 2009 Jun;36(2):257-70. doi: 10.1016/j.pop.2009.01.006.

Leeder SR. The history of insulin: the mystery of diabetes. Med J Aust. 2013 Aug 19;199(4):227.

Lorenzo C, Wagenknecht LE, D’Agostino RB Jr, Rewers MJ, Karter AJ, Haffner SM. Insulin resistance, beta-cell dysfunction, and conversion to type 2 diabetes in a multiethnic population: the Insulin Resistance Atherosclerosis Study. Diabetes Care. 2010 Jan;33(1):67-72. doi: 10.2337/dc09-1115. Epub 2009 Oct 6.

Reusch JE. Focus on insulin resistance in type 2 diabetes: therapeutic implications. Focus on insulin resistance in type 2 diabetes: therapeutic implications. Diabetes Educ. 1998 Mar-Apr;24(2):188-93.

Indian gooseberry (Embolic officials), or amla, is a traditional food in its native India. It’s also an important plant used in the Indian traditional system of healing, Ayurveda. In fact, one research team refers to it as “arguably the most important medicinal plant in the Indian traditional system of medicine, the Ayurveda.” Writing in the European Journal of Cancer Prevention, the authors note that amla is reputed to possess anti-inflammatory activity as well as the ability to lower cholesterol, prevent atherosclerosis, and protect various organs, including the heart, stomach, liver and nervous system. It’s even been claimed to help prevent hair loss, and surprisingly, there is preliminary evidence to support this seemingly outlandish claim. Meanwhile, preliminary work with animal models of human disease suggest amla may reduce the complications of type 2 diabetes.

Anti-inflammatory and Antioxidant Activity

The ripe fruit is described as sour, astringent, and bitter, but extracts of amla, taken as dietary supplements, are of more interest to Westerners. Some of those bitter and astringent flavors can be attributed to high concentrations of compounds called ellagitannins. Like many herbal products used in Ayurveda, amla is reported to possess multiple beneficial activities. Modern research indicates that a primary benefit of this plant and its extracts is its anti-inflammatory activity. Preliminary research indicates it significantly reduces several pro-inflammatory cytokines, including tumor necrosis factor-alpha and interleukin-6. These chemicals have been implicated in a number of diseases.

Animal studies suggest that amla extract may provide significant antioxidant benefits. In one study, laboratory rats with induced heart disease were spared by amla. They showed evidence of less heart muscle damage, and higher levels of important natural antioxidants, than rats that did not receive amla. Amla also prevented the oxidation of blood lipids. Lipid peroxidation is one of the common factors that indicate oxidative stress. Lipid peroxidation is linked to the development of atherosclerosis and cardiovascular disease.

Other studies on animal models of human disease support amla’s beneficial effects on the lipid profile. Amla appears to boost levels of “good” HDL-cholesterol and decrease levels of “bad” LDL-cholesterol. Amla also appears to lower levels of triglycerides and may even provide some protection against the development of insulin resistance, despite a diet high in fructose. Early animal studies suggest that amla can prevent the development and progression of salt-induced high blood pressure, while also protecting the natural antioxidant defense systems.

Hair loss prevention?

Male pattern baldness is the name given to the most common type of baldness. It affects up to 70% of men. This type of hair loss results from a combination of genetic susceptibility interacting with certain hormones. Among susceptible men, testosterone is converted in the body to a hormone called dihydroxytestosterone (DHT). DHT, in turn, indirectly causes the hair follicles of the temple and crown of the head to shrink to the point that no new hair grows.

In the late 1990s, scientists realized that a drug initially approved for the treatment of benign prostatic hyperplasia (BPH), or enlarged prostate, also tended to prevent or reverse male pattern baldness among some patients. The drug was eventually approved for hair loss prevention. It works by inhibiting an enzyme involved in the hair loss process, 5-alpha reductase. For centuries, Ayurveda prescribed the use of amla for hair loss prevention. Now modern research has demonstrated that certain chemicals in amla work to inhibit 5-alpha reductase, just as modern pharmaceuticals do.

Reduced Diabetic Complications

Emerging research, using animal models of type 2 diabetes, indicates that amla extract may reduce the risk of diabetic complications, primarily by normalizing impaired antioxidant status. The extract yielded lower blood sugar levels among diabetic rats treated with the herb, for example, and prevented the depletion of important natural antioxidants, such as glutathione and superoxide dismutase. What’s more, other test animals treated with a common prescription anti-diabetes drug, rather than amla, did not fare as well. “The extract exerted rapid protective effects…reducing the risk of diabetic complications,” researchers wrote.

References

Baliga MS, Dsouza JJ. Amla (Emblica officinalis Gaertn), a wonder berry in the treatment and prevention of cancer. Eur J Cancer Prev. 2011 May;20(3):225-39. doi: 10.1097/CEJ.0b013e32834473f4.

Bhatia J, Tabassum F, Sharma AK, Bharti S, Golechha M, Joshi S,  Emblica officinalis exerts antihypertensive effect in a rat model of DOCA-salt-induced hypertension: role of (p) eNOS, NO and oxidative stress. Cardiovasc Toxicol. 2011 Sep;11(3):272-9. doi: 10.1007/s12012-011-9122-2.

Golechha M, Bhatia J, Arya DS. Studies on effects of Emblica officinalis (Amla) on oxidative stress and cholinergic function in scopolamine induced amnesia in mice. J Environ Biol. 2012 Jan;33(1):95-100.

Kalekar SA, Munshi RP, Bhalerao SS, Thatte UM. Insulin sensitizing effect of 3 Indian medicinal plants: an in vitro study. Indian J Pharmacol. 2013 Jan-Feb;45(1):30-3. doi: 10.4103/0253-7613.106431.

Koshy SM, Bobby Z, Hariharan AP, Gopalakrishna SM. Amla (Emblica officinalis) extract is effective in preventing high fructose diet-induced insulin resistance and atherogenic dyslipidemic profile in ovariectomized female albino rats. Menopause. 2012 Oct;19(10):1146-55.

Kumar N, Rungseevijitprapa W, Narkkhong NA, Suttajit M, Chaiyasut C. 5α-reductase inhibition and hair growth promotion of some Thai plants traditionally used for hair treatment. J Ethnopharmacol. 2012 Feb 15;139(3):765-71. doi: 10.1016/j.jep.2011.12.010. Epub 2011 Dec 13.

Libecco JF, Bergfeld WF. Finasteride in the treatment of alopecia. Expert Opin Pharmacother. 2004 Apr;5(4):933-40.

Michaud M, Balardy L, Moulis G, Gaudin C, Peyrot C, Vellas B, et al. Proinflammatory Cytokines, Aging, and Age-Related Diseases. J Am Med Dir Assoc. 2013 Jun 20. pii: S1525-8610(13)00280-6. doi: 10.1016/j.jamda.2013.05.009. [Epub ahead of print]

Nain P, Saini V, Sharma S, Nain J. Antidiabetic and antioxidant potential of Emblica officinalis Gaertn. leaves extract in streptozotocin-induced type-2 diabetes mellitus (T2DM) rats. J Ethnopharmacol. 2012 Jun 26;142(1):65-71.

Ojha S, Golechha M, Kumari S, Arya DS. Protective effect of Emblica officinalis (amla) on isoproterenol-induced cardiotoxicity in rats. Toxicol Ind Health. 2012 Jun;28(5):399-411. doi: 10.1177/0748233711413798. Epub 2011 Oct 27.

Wongpradabchai S, Chularojmontri L, Phornchirasilp S, Wattanapitayakul SK. Protective effect of Phyllanthus emblica fruit extract against hydrogen peroxide-induced endothelial cell death. J Med Assoc Thai. 2013 Jan;96 Suppl 1:S40-8.

For thousands of years, indigenous peoples living in the foothills of the mighty Himalayas have made use of a remarkable array of native plants for healing and maintaining wellness. Modern scientists have investigated many of these herbs. In some cases, the plants in question yield remarkable compounds that have received an extraordinary amount of attention.

For instance, Ayurveda, the ancient system of medicine practiced for thousands of years in India, is responsible for introducing the modern world to curcumin. Curcumin is the name given to a group of chemical compounds in the curry spice, turmeric. In addition to being an important culinary spice, it’s an equally important medicinal herb. Modern science shows that it contains powerful antioxidant and anti-inflammatory compounds. This medicinal herb is under intense scrutiny by scientists around the world, due to its many perceived beneficial properties, including possible anti-cancer activity. It is arguably among the most studied plants on the planet.

Mysterious panacea

And then there’s Shilajit. Also valued in Ayurveda, this substance is far more mysterious. Everything from its origins to its composition is shrouded in a high-altitude fog of mystery. Shilajit is described as a “bituminous substance” found more or less oozing from cracks in rocks high in the Himalaya Mountains of northern India and Tibet. According to Asian scientists, it consists of vegetable matter of indeterminate identity, which has undergone decomposition by microbes. The undefined nature of these plants, minerals and microorganisms, and the difficulty in sourcing Shilajit, have all contributed to its mystique.

Contemporary Asian scientists have attempted to identify specific compounds in Shilajit to determine its active ingredients. In Ayurveda, Shilajit is credited with being able to treat a wide range of aliments and complaints, ranging from diabetes, bladder disease and kidney stones, to anemia, anorexia and even tuberculosis. The list doesn’t end there. Modern investigators suggest it may be useful for controlling “cognitive disorders associated with aging.” In essence, Shilajit is believed to be a panacea, or universal cure, in Ayurveda. “There is hardly any curable diseases which cannot be controlled / cured with the aid of Shilajit,” researchers wrote recently, paraphrasing some of the folklore beliefs surrounding Shilajit.

Because it is so rare, and its origins so mysterious, it has been difficult for scientists to definitively identify its active ingredients, or to study its efficacy. In 2003, Indian investigators in the Department of Biochemistry at SMS Medical College in Jaipur conducted a clinical trial on the effects of Shilajit on the blood chemistry of healthy human subjects. The blinded, placebo-controlled trial showed that purified Shilajit was safe and well tolerated, even at doses of two grams per day. Liver function was not affected, but there were improvements in the blood lipid profile, including drops in total and LDL-cholesterol, and triglyceride levels, and healthy increases in “good” HDL-cholesterol.

Antioxidant and hypolipidemic activity

The ancient remedy also improved subjects’ levels of important antioxidants, such as vitamin C, vitamin E, and the natural antioxidant enzyme, superoxide dismutase, which prevents the peroxidation of cholesterol into its more harmful forms.

Investigators concluded that Shilajit has “hypolipidemic and antioxidant action,” which should protect against oxidative stress and help normalize abnormal blood lipid profiles. They and other researchers have identified numerous compounds in Shilajit, including benzopyrones and fulvic acid. Most experts agree that fulvic acid in Shilajit is probably responsible for many of its benefits. Fulvic acid is a “bi-directional super antioxidant,” capable of either accepting or supplying unpaired electrons, as needed, to neutralize potential oxidants in the body.

References

Agarwal SP, Khanna R, Karmarkar R, Anwer MK, Khar RK. Shilajit: a review. Phytother Res. 2007 May;21(5):401-5.

Carrasco-Gallardo C, Farías GA, Fuentes P, Crespo F, Maccioni RB. Can nutraceuticals prevent Alzheimer’s disease? Potential therapeutic role of a formulation containing shilajit and complex B vitamins. Arch Med Res. 2012 Nov;43(8):699-704. doi: 10.1016/j.arcmed.2012.10.010. Epub 2012 Nov 3.

Carrasco-Gallardo C, Guzmán L, Maccioni RB. Shilajit: a natural phytocomplex with potential procognitive activity. Int J Alzheimers Dis. 2012;2012:674142. doi: 10.1155/2012/674142. Epub 2012 Feb 23.

Kizaibek M. [Research advances of Tasmayi]. Zhongguo Zhong Yao Za Zhi. 2013 Feb;38(3):443-8.

Meena H, Pandey HK, Arya MC, Ahmed Z. Shilajit: A panacea for high-altitude problems. Int J Ayurveda Res. 2010 Jan;1(1):37-40. doi: 10.4103/0974-7788.59942.

Schepetkin IA, Khlebnikov AI, Ah SY, Woo SB, Jeong CS, Klubachuk ON, et al. Characterization and biological activities of humic substances from mumie. J Agric Food Chem. 2003 Aug 27;51(18):5245-54.

Schepetkin IA, Xie G, Jutila MA, Quinn MT. Complement-fixing activity of fulvic acid from Shilajit and other natural sources. Phytother Res. 2009 Mar;23(3):373-84. doi: 10.1002/ptr.2635.

Sharma P, Jha J, Shrinivas V, Dwivedi LK, Suresh P, Sinha M. Shilajit: evalution of its effects on blood chemistry of normal human subjects. Anc Sci Life. 2003 Oct;23(2):114-9.

Stohs SJ. Safety and Efficacy of Shilajit (Mumie, Moomiyo). Phytother Res. 2013 Jun 3. doi: 10.1002/ptr.5018. [Epub ahead of print]

Surapaneni DK, Adapa SR, Preeti K, Teja GR, Veeraragavan M, Krishnamurthy S. Shilajit attenuates behavioral symptoms of chronic fatigue syndrome by modulating the hypothalamic-pituitary-adrenal axis and mitochondrial bioenergetics in rats. J Ethnopharmacol. 2012 Aug 30;143(1):91-9. doi: 10.1016/j.jep.2012.06.002. Epub 2012 Jul 6.

Velmurugan C, Vivek B, Wilson E, Bharathi T, Sundaram T. Evaluation of safety profile of black shilajit after 91 days repeated administration in rats. Asian Pac J Trop Biomed. 2012 Mar;2(3):210-4. doi: 10.1016/S2221-1691(12)60043-4.

Wilson E, Rajamanickam GV, Dubey GP, Klose P, Musial F, Saha FJ, Rampp T, et al. Review on shilajit used in traditional Indian medicine. J Ethnopharmacol. 2011 Jun 14;136(1):1-9. doi: 10.1016/j.jep.2011.04.033. Epub 2011 Apr 20.

We all know that true weight loss requires a healthy diet and exercise program.  That doesn’t mean that there aren’t tools you can use to get better results, faster.  Check out this new video on Meratrim – and if you’re interested in the most advanced Meratrim product available, take a look at SLIMit with Meratrim.

New Research Shows How To Overcome This and Lose At least 2.7 Inches In Only 2 weeks…

By Jim Caras

Unknown to many who struggle losing weight and shaping their body, scientists have recently identified a new group of naturally occurring “slimming” hormones  that actually prevent us from losing fat  – regardless of how much we diet and exercise.

For most, this may finally explain why losing weight in the most visible areas – the waist, hips, and thighs – has been futile.   Fortunately, a group of natural compounds has been discovered that can quickly correct this. This exciting compound promise to dramatically reshape bodies in as little as two weeks without any harmful stimulants, drugs, or invasive surgery!

“Diet-Resistant” Fat

SLIMit with Meratrim provides 100% Pure Meratrim plus five advanced slimming agents

Why you’ve had trouble losing fat can now be explained quite simply.

Although fat cells exist throughout the body, most accumulate around our waist, hips, and thighs.  As we gain weight, the “fat-storage” cells expand, leading to an undesirable body shape and serious potential health problems.

When fewer calories are consumed, or more energy is expended due to activities like exercise, fat is normally released from “fat-storage” cells and used as energy.  Unfortunately for many of us, it doesn’t work this way.

THE PROBLEM IS our bodies’ natural “slimming” hormones begin to work against us.  Often ignored by health experts, these hormones simultaneously increase fat storage and prevent fat from breaking down – even when cutting calories and exercising.  The result is “diet-resistant” fat that builds up in your belly, waist, hips, and thighs.

The New Attack on Fat

Fortunately, recent scientific research has shown that a natural compound of herbs, minerals, and antioxidants (see side-bar) can help correct these weight-loss-hindering processes.

Studies show that these ingredients unlock fat storage, while simultaneously stimulating the body’s natural fat-burning hormones – all without caffeine or harmful stimulants!

The result is a “four-pronged” attack on pounds and inches by:

  • Unlocking Fat Storage:  By inhibiting Perilipin, the fat storage hormone that surrounds fat, preventing it from breaking down.*
  • Boosting Fat-Burning:  By helping boost the hormone Adiponectin, which burns fat.*
  • Improving Fat Utilization:   By supporting healthy Insulin within normal levels. This hormone helps regulate fat utilization, food cravings, and mood.*
  • Stopping Fat Cell Formation:  By also helping prevent the formation of new fat cells, adding to its slimming effects.*

Clinical Studies Show Results In Only 2 Weeks!

What’s different from most weight loss products is that this new natural compound works quickly and is backed by four human clinical trials. These include randomized, double-blind, placebo-controlled studies – the same gold standard used by the FDA to evaluate pharmaceutical drugs.

The body slimming results showed an impressive 2.7 inches lost in as little as two weeks in the waist and hips!  And continued use for eight weeks resulted in 7.2 inches lost and 8½ MORE pounds lost compared to the placebo group.

10xs BETTER Results Than Garcinia Cambogia, Raspberry Ketone, and CLA

In fact, natural ingredients in this compound are clinically shown to provide 10 times more inches lost in the waistline and more weight lost in LESS TIME, than the most popular weight loss products made popular by Dr Oz:  Garcinia Cambogia and Raspberry Ketones.

And their results are even greater when comparing them to one of the most well-known weight loss products, CLA.  Plus, they perform even better than Green Coffee Extract and many popular over-the-counter diet products.

Safe with NO Harmful Stimulants

The other advantage of this hormonal-correcting-compound is that it only directly targets and affects fat cells, offering a safe alternative.

The problem with commonly used caffeine and stimulant weight loss products is that they stimulate weight loss by working by through other body systems, like the central nervous system, heart, and thyroid.  This oftentimes leads to unwanted or potentially dangerous side-effects, including nervousness, poor sleep, heart palpitations and a counterproductive reversal or drop in the metabolism when discontinued.

“Jump-Starts” ANY Diet and Weight Loss Supplements

By utilizing a unique and safe mechanism for reducing fat stores, another advantage is that this new compound can be used in conjunction with other weight loss products and on any diet program.  This allows users to see immediate results, which helps keep them on the weight loss regimen.

Whether you want to quickly lose a few inches and pounds or aggressively lose much more and really transform your physique, the use of this new natural compound will make your slimming and weight loss goals much more achievable, quicker and easier.

Editor’s Note on Availability

Although this new slimming compound is relatively new, the good news for consumers is that it’s quickly making its way onto select health food retailer’s shelves now, under the brand name SLIMit™, from the American company, Health Direct.

Author’s Bio

Jim Caras is the author of the bestselling weight loss book, How To Completely Reshape Your Body!, a nutrition trainer and lecturer, and the founder of Health Direct.

Editor’s Note:  Although this revolutionary slimming compound is relatively new, the good news for consumers is that it is quickly making its way onto select health food retailer’s shelves now, under the brand name SLIMit™ from Health Direct

You do everything right.  You diet and exercise, but those extra unsightly pounds around your waist and hips don’t seem to come off.

If this sounds like you – don’t worry – you are not alone.  Many people are victims of what weight loss experts now identify as “Diet-Resistant Fat.”

But there is good news.  Scientists have recently found a special combination of natural plant extracts and minerals that are able to literally “unlock” these fat stores so they can be quickly and easily burned off.

Sound too good to be true?  Solid scientific studies back this new discovery – and it promises to revolutionize how we lose weight.

What is “Diet-Resistant Fat”?

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Why you’ve had trouble losing fat can now be explained quite simply.

Weight loss author Jim Caras coined the term “Diet-Resistant Fat,” when searching for a solution to help his clients shed those hard to lose pounds and inches.  He explains:

“Although fat cells exist throughout the body, most accumulate around our waist, hips, and thighs.  As we gain weight, these “fat-storage” cells expand, leading to an undesirable body shape and potentially serious health problems.  When fewer calories are consumed, or more energy is expended due to activities like exercise, fat is normally released from “fat-storage” cells and used as energy.  Unfortunately for many of us, it doesn’t work this way.”

Caras continues, “THE PROBLEM IS our bodies’ natural “slimming” hormones begin to work against us.  Often ignored by health experts, these hormones simultaneously increase fat storage and prevent fat from breaking down – even when cutting calories and exercising.  The result is “Diet-Resistant Fat” that builds up in your belly, waist, hips, and thighs.”

Perilipin – The Key to Unlocking Stubborn Fat Cells

Perilipin is one of the key mechanisms in how your body stores fat, but chances are you’ve never heard of it.  This little-known hormone plays a big role in any effort you may make to slim your body.

Perilipin coats droplets of fat (lipids) that are in the body’s fat-storage cells.  Scientists who study body fat have discovered that fat droplets wrapped in Perilipin are resistant to the effects of lipase, an enzyme involved in the breakdown of stored lipids.  If lipase can’t reach the lipids stored in fat cells, it can’t initiate the breakdown and elimination of those lipids.

Blocking the production of this hormone makes it easier for lipase to break down lipid droplets in fat cells, leading to significant weight loss.

Adiponectin – The Hormone That Burns Fat More Quickly

Adiponectin is the most abundant hormone in fat cells and among the most abundant in circulation throughout your entire body.  It stimulates cells to burn fatty acids for energy. This increases insulin sensitivity and helps reduce levels of triglycerides circulating in the bloodstream.

Ironically, the fatter a person is the less Adiponectin they have circulating in their bloodstream. Likewise, a thinner person or those with fewer fat cells have more Adiponectin.

While weight loss (the reduction of fat cells) can result in dramatic increases in Adiponectin, researchers have been scrambling to identify dietary supplements that may help boost levels of Adiponectin – until now.

Extraordinary Science

After extensive research, scientists have finally identified a specific combination of plant and fruit extracts, minerals, and antioxidants that simultaneously help inhibit Perilipin and increase Adiponectin.

This new stimulant-free compound includes:  Resveratrol: (a powerful antioxidant), Purple Mangosteen a.k.a. Garcinia Mangostana (an exotic fruit), Shilajit (a purified mineral complex), and East Indian Globe Thistle a.k.a. Sphaeranthus indicus (restorative flower used in Ayurvedic medicine).

And what’s different from most weight loss products is that this new natural compound works quickly and its ingredients are backed by four human clinical trials.  These include randomized, double blind, placebo-controlled studies – the same gold standard used by the FDA to evaluate pharmaceutical drugs.

“The research is extraordinary.  There’s simply nothing out there like it,” says Caras.  “The core ingredients are a major advancement over harmful stimulant weight loss products that can really damage your health.  They even help support healthy insulin within normal levels and prevent new fat cells from forming – which is unheard of,” he continues.

Reduces Belly Fat Fast

The combination of inhibiting Perilipin and increasing Adiponectin has shown to pack a powerful punch in reducing fat.

Clinical studies involving 100 subjects showed an impressive 2.7 inches lost in as little as two weeks in the waist and hips – a whopping 4½ times more than compared to the placebo group.

And the results continued with use for eight weeks resulting in 7.2 inches lost in the waist and hips and 8½ MORE pounds lost compared to the placebo group.

“What is impressive,” claims Caras, “Is that the study participants consumed a generous 2,000 calorie a day diet and only walked for 30 minutes per day, five days per week.  This is totally achievable.” Caras continues, “The problem with many other weight loss studies is that the participants consume an unusually low amount of calories and exercise very strenuously, which is unrealistic.”

Body Shaping Success At Last

Whether you want to quickly lose a few inches and pounds, or aggressively lose much more and really transform your physique, the use of this new natural compound will make your slimming and weight loss goals quicker, easier, and much more achievable.

Editor’s Note:  Although this revolutionary slimming compound is relatively new, the good news for consumers is that it is quickly making its way onto select health food retailer’s shelves now, under the brand name SLIMit® with Meratrim® from Health Direct

Perilipin has a say in how your body stores fat, but chances are you’ve never heard of this family of proteins. Also known as lipid-droplet associated protein, perilipin coats tiny droplets of fat (lipids) within the body’s fat-storing cells. This little-known protein plays an outsized role in any effort you may make to downsize your body.

Scientists who study body fat—and how to manage it—have discovered that fat droplets wrapped in perilipin are resistant to the effects of lipase, an enzyme involved in the breakdown of stored lipids. And that, of course, makes perilipin a potentially important player in the “battle of the bulge.” If lipase can’t reach the lipids stored in fat cells, it can’t initiate the breakdown and elimination of those lipids.

At times it seems all too easy: Eat that greasy, sugary doughnut, and you’re pretty much guaranteed to gain a little more weight, seemingly overnight. In short: it will make you fat. This dovetails with the commonly accepted model of weight gain, which maintains that if you consume more calories in a day than you burn, weight gain will occur. And weight gain means “you’ll get fatter.” As it turns out, the storage, buildup and breakdown of lipids (fat) in the body is fairly complicated.

Weight Gain: Easy to Achieve, Hard to Control

To better understand the role of perilipin in weight control, it’s helpful to review how the doughnut you eat is converted from a sugary treat to jiggly fat. When you eat carbohydrates— which include everything from the starch in potatoes to the sugar in your coffee—the carb molecules are converted to their simplest components. And that means glucose. Cells can burn glucose directly for energy, but excess glucose is converted, through a series of steps, into fatty acids, which are then stored in fat cells (adipocytes). This process is called lipogenesis. Of course, fat in the diet is also broken down, into components called triglycerides. These too may end up swelling fat cells with stored lipids.

These processes allow the body to store up calories as a hedge against future times of starvation. But of course, these days food is cheap and readily available. So an old survival mechanism is now working against us.

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east-indian-globe-thistleYou’ve probably never heard of Sphaeranthus indicus, but chances are you will soon. It’s poised to become one of the latest in a long line of beneficial botanicals that have been introduced to the West by Ayurveda, the ancient Indian system of medicine.

Although Sphaeranthus indicus is a common weed in India, it’s long been valued there for its reputed medicinal properties. According to Ayurveda, serves many useful, diverse functions. But its effects on weight management are likely to get the most attention from Westerners. That’s right. There’s another new weight-loss herb about to enter the crowded marketplace: Sphaeranthus indicus.

Read More »

pepper-packs-an-antioxidant-punchPiperine is a beneficial natural ingredient you’ve probably never heard of, but have almost certainly consumed. It’s one of the potent active compounds in ordinary black pepper. Of course, people have prized pepper (Piper nigrum) as a culinary spice and food preservative for centuries. Along with commodities like cinnamon and cloves, the trade in black pepper arguably fueled the expansion of Western civilization. In ancient times pepper served a crucial role in food preservation. It also added a welcome spark of flavor to otherwise bland dishes. In its native India, black pepper has been used in the traditional Ayurveda system of medicine for centuries. Read More »

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